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KMID : 0895820110210020101
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Journal of Oriental Rehabilitation Medicine
2011 Volume.21 No. 2 p.101 ~ p.123
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The Effect of Bee Venom Pharmacopuncture Therapy The Effect of Bee Venom Pharmacopuncture Therapy in Rheumatoid Arthritis Rat Model
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Yu Deok-Seon
Yeom Seung-Ryong
Lee Su-Kyung
Kwon Young-Dal
Song Yung-Sun
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Abstract
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Objectives: The aim was to study the effect of bee venom pharmacopuncture therapy with different concentration on rheumatoid arthritis rat model.
Methods: We enforced a bee venom pharmacopuncture therapy with different concentration on rheumatoid arthritis rat model by the intradermal injection of chicken type Ⅱ collagen emulsified. 14 days after the onset of the rheumatoid arthritis rat model, a fixed volume of bee venom was daily injected to ST-35 acupoint in the rat`s knee joint for 2-3 weeks. The hind paw volume, arthritic index, arthritic flexion pain test, pain threshold, and serum analysis(CRP, PGE2, ALT, AST) were analyzed, and the expression profiles of COX-2, c-fos, and substance-P at the dorsal horn region of the spinal cord and subchondral bone of the knee joint were also analyzed by using the immunohistochemistry.
Results: After the treatment of rheumatoid arthritis rats with bee venom pharmacopuncture, the paw volume of edema of arthritic rats were almost restored to the level of normal group, and behavior tests were very effective. Also the evaluation on the blood serum analysis was remarkable. COX-2, c-fos, and substance-P positive cells in the immunohistological section of dorsal horn region of the spinal cord and subchondral bone of the knee joints were significantly decreased. also the bee venom pharmacopuncture was effective to alleviate their rheumatoid arthritic inflammation cytokine inhibition as regards to the behavior tests and joint histological appearance.
Conclusions: Based on the results in this study, bee venom pharmacopuncture with concentrated treatment condition was very effective in low fixed quantity and progressive low increased quantity.
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KEYWORD
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Bee venom pharmacopuncture therapy, Concentrated treatment condition, Rheumatoid arthritis
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